Douglas B Kell Selected Research

estropipate (Ogen)

1/2021	SARS-CoV-2 spike protein S1 induces fibrin(ogen) resistant to fibrinolysis: implications for microclot formation in COVID-19.
11/2020	Is Porphyromonas gingivalis involved in Parkinson's disease?
7/2020	Covid-19: The Rollercoaster of Fibrin(Ogen), D-Dimer, Von Willebrand Factor, P-Selectin and Their Interactions with Endothelial Cells, Platelets and Erythrocytes.
1/2019	A Possible Role of Amyloidogenic Blood Clotting in the Evolving Haemodynamics of Female Migraine-With-Aura: Results From a Pilot Study.
1/2015	The simultaneous occurrence of both hypercoagulability and hypofibrinolysis in blood and serum during systemic inflammation, and the roles of iron and fibrin(ogen).

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Douglas B Kell Research Topics

Disease

15	Inflammation (Inflammations) 01/2022 - 01/2009
11	Alzheimer Disease (Alzheimer's Disease) 01/2020 - 01/2013
8	COVID-19 01/2022 - 01/2020
7	Thrombosis (Thrombus) 01/2021 - 11/2018
7	Parkinson Disease (Parkinson's Disease) 12/2020 - 04/2013
7	Pre-Eclampsia (Preeclampsia) 01/2020 - 07/2008
6	Infections 01/2022 - 11/2002
5	Disease Progression 07/2020 - 04/2006
5	Thrombophilia 01/2019 - 01/2015
4	Type 2 Diabetes Mellitus (MODY) 11/2020 - 03/2015
4	Dementia (Dementias) 11/2018 - 01/2016
3	Neuroinflammatory Diseases 12/2020 - 11/2015
2	Cardiovascular Diseases (Cardiovascular Disease) 01/2022 - 01/2022
2	Post-Acute COVID-19 Syndrome 01/2022 - 01/2021
2	Dysbiosis 12/2020 - 01/2018
2	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 11/2018 - 01/2018
2	Necrosis 03/2012 - 02/2011
2	Tuberculosis (Tuberculoses) 11/2002 - 11/2002
1	Drug-Related Side Effects and Adverse Reactions 09/2021
1	Thrombotic Microangiopathies 11/2020
1	Nervous System Diseases (Neurological Disorders) 11/2020
1	Periodontal Diseases (Periodontal Disease) 11/2020
1	Cytokine Release Syndrome 07/2020
1	Rheumatoid Arthritis 01/2020
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2020
1	Ischemia 01/2020
1	Acute-Phase Reaction 01/2019
1	Migraine Disorders (Migraine) 01/2019
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2019
1	Migraine with Aura (Familial Hemiplegic Migraine) 01/2019
1	Huntington Disease (Huntington's Disease) 01/2019
1	Multiple Organ Failure (MODS) 04/2018
1	Sepsis (Septicemia) 04/2018
1	Systemic Inflammatory Response Syndrome (Sepsis Syndrome) 04/2018
1	Prion Diseases (Transmissible Spongiform Encephalopathies) 04/2018
1	Disseminated Intravascular Coagulation 04/2018
1	Septic Shock (Toxic Shock Syndrome) 04/2018
1	Communicable Diseases (Infectious Diseases) 01/2018
1	Pancreatic Neoplasms (Pancreatic Cancer) 01/2017
1	Endotoxemia 01/2016
1	Cognitive Dysfunction 01/2016
1	Memory Disorders (Memory Loss) 11/2015

Drug/Important Bio-Agent (IBA)

16	FibrinIBA 01/2022 - 06/2013
13	IronIBA 12/2020 - 01/2009
11	Amyloid (Amyloid Fibrils)IBA 01/2022 - 01/2017
10	Biomarkers (Surrogate Marker)IBA 07/2020 - 04/2006
9	Proteins (Proteins, Gene)FDA Link 01/2022 - 11/2002
9	LipopolysaccharidesIBA 01/2022 - 11/2015
7	Fibrinogen (Factor I)FDA Link 07/2020 - 05/2014
5	AntioxidantsIBA 01/2022 - 01/2018
5	estropipate (Ogen)FDA LinkGeneric 01/2021 - 01/2015
5	Ferritins (Ferritin)IBA 11/2020 - 01/2013
4	ErgothioneineIBA 01/2022 - 01/2018
4	CytokinesIBA 01/2019 - 11/2015
3	Transcription Factors (Transcription Factor)IBA 03/2012 - 12/2006
3	NF-kappa B (NF-kB)IBA 02/2011 - 12/2006
2	Pharmaceutical PreparationsIBA 09/2021 - 01/2016
2	Oxygen (Dioxygen)IBA 01/2021 - 01/2020
2	SynucleinsIBA 12/2020 - 04/2013
2	P-SelectinIBA 11/2020 - 07/2020
2	Gingipain Cysteine EndopeptidasesIBA 01/2020 - 01/2019
2	Therapeutic UsesIBA 01/2020 - 01/2018
2	Peptide Hydrolases (Proteases)FDA Link 01/2020 - 01/2019
2	lipopolysaccharide-binding proteinIBA 01/2018 - 01/2018
2	EndotoxinsIBA 01/2016 - 11/2015
2	Chelating AgentsIBA 01/2016 - 01/2014
2	Hydroxyl RadicalIBA 01/2015 - 01/2009
1	Hemostatics (Antihemorrhagics)IBA 01/2022
1	AutoantibodiesIBA 01/2022
1	Nucleic AcidsIBA 12/2021
1	Lipid Bilayers (Lipid Bilayer)IBA 09/2021
1	muramyl- NAc- (pentapeptide)pyrophosphoryl- undecaprenolIBA 09/2021
1	Antifibrinolytic Agents (Antifibrinolytics)IBA 01/2021
1	SARS-CoV-2 spike proteinIBA 01/2021
1	Coloring Agents (Dyes)IBA 11/2020
1	fibrin fragment D (D-dimer)IBA 07/2020
1	von Willebrand FactorIBA 07/2020
1	VitaminsIBA 01/2020
1	LactoferrinIBA 01/2020
1	KynurenineIBA 01/2019
1	EnzymesIBA 01/2019
1	ProdrugsIBA 01/2019
1	Acute-Phase Proteins (Acute-Phase Protein)IBA 01/2019
1	Kynurenine 3-Monooxygenase (Kynurenine 3 Monooxygenase)IBA 01/2019
1	Amyloidogenic ProteinsIBA 01/2019
1	Monoclonal AntibodiesIBA 11/2018
1	thioflavin TIBA 11/2018
1	PrionsIBA 04/2018
1	VaccinesIBA 01/2018
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2018
1	NeurograninIBA 07/2017
1	Gemcitabine FDA Link 01/2017
1	NucleosidesIBA 01/2017
1	Thrombin FDA Link 03/2015
1	Interleukin-6 (Interleukin 6)IBA 01/2015

Therapy/Procedure

5	Therapeutics 01/2021 - 04/2006
1	Operative Surgical Procedures 01/2022
1	Oral Hygiene (Dental Hygiene) 11/2020
1	Precision Medicine 07/2020
1	Resuscitation 01/2016